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KMID : 1001020210190020079
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Journal of Urologic Oncology
2021 Volume.19 No. 2 p.79 ~ p.81
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An Update of Gonadotropin-Releasing Hormone Antagonists in the Treatment of Advanced Prostate Cancer
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Hong Jeong-Hee
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Abstract
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For decades, androgen deprivation therapy (ADT) was the cornerstone treatment for advanced prostate cancer. ADT using gonadotropin-releasing hormone (GnRH) agonist or antagonist acts by blocking the hypothalamic-pituitary-gonadal system with different mechanism. Both injectable GnRH agonist and antagonist are currently used as a standard of care. The novel oral GnRH antagonist has recently approved and it may have a promising alternative to the conventional ADT. This review will focus on the history of drug development, efficacy and safety profiles for GnRH antagonists in patients with prostate cancer.
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KEYWORD
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Prostate cancer, Gonadotropin-releasing hormone, Antagonist
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